Plume, a digital health platform for transgender patients, offers access to digital consultations and gender-affirming healthcare. Plume aims to give each transperson immediate access to gender-affirming hormone therapy via the smartphone. The platform offers home delivery of hormone therapy, which distinguishes Plume from other healthcare platforms. In addition, membership covers the associated healthcare and laboratory costs. The founders’ vision is to simplify transgender healthcare for all. As such, Plume contributes to an improved (digital) healthcare landscape and higher patient satisfaction among this group.